SMS app note 301

SMS Application Note

Introduction
The increasing sophistication of pharmaceutical drugs and drug delivery technologies has created the need for new techniques to measure the physico-chemical properties of a wide range of solid pharmaceutical ingredients and formulations. Inverse gas chromatography (IGC SEA) is a gas phase technique, first developed over 40 years ago, to study the surface and bulk properties of particulate and fibrous materials. IGC SEA has the potential to unlock some of the more difficult to measure physico-chemical properties of pharmaceutical materials such as powder surface energies, acid/base/polar functionality of surfaces, diffusion kinetics, solubility parameters, surface heterogeneity and phase transition temperatures/humidities.

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